CYP2D6 (Cytochrome P450 2D6Phenotyping) in Vivax Malaria Relapsers and Non-Relapsers

Period: Apr 2014 - Okt 2014

Fund: Medicine for Malaria Venture (MMV)

This project was a controlled case study on the slow medium fast metabolism frequency of CYP2D of single dose dextrometorfan on relapsers after direct monitored primaquine therapy compared to non-relapsers. The secondary objective was to compare the phenotype and genotype of CYP2D6 to compare the pharmacokinetic primaquine with phenotype and genotype status. The study subjects were Indonesian Army soldiers at Battalion 408H.

In this study ALERTAsia was responsible for the grant management and procurements. A team from EOCRU supported the study by making sure everything was executed according to plans.

Genotype tests team:
Prof. HerawatiSudoyo, PhD
Dr. Farah Coutier
Phenotype tests team from Pharmacology at University of Indonesia:
Prof. RiantoSetiabudi
Dr.Melva Louisa
dr. Anggi Gayatri

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